Hydrothermal Preparation of Faceted Vesicles Made of Span 40 and Tween 40 and Their Characterization

The Span 40 (sorbitan monooleate)/Tween (polyoxyethylene sorbitan monolaurate) system gives faceted vesicles with angular surfaces, rather than spherical vesicles. Herein, a continuous and facile preparation method, based on the subcritical water-assisted emulsification solvent diffusion, was presented to yield two major minor axes (Type A) closer polyhedron B). Type A, B, were likely be formed. From measurements concerning ζ-potential, membrane fluidity, polarization environment of membranes, could obtained at 0.25 wt% surfactant concentration. phase-separated behavior Tween within vesicle membranes explain structural feature calcein leakage behavior. significant advantage is that A would utilized as alternative drug carriers for others low encapsulation efficiency, although present technical limitations cause difficulty in selective formation B selection adequate accelerate diffusion step.